His reply has gone viral. Here's the vid, with the transcript below:
I was...lucky. I was good at - and liked - Teh Sports (Go Sports! Yay!), and hung out with gamers and "jocks" alike. I never had to suffer what some of my friends did, and I spoke up and spoke out. In retrospect, I should have done it even more. In retrospect, nobody should ever have to apologize for or have someone stick up for loving what (OR WHOM) they love.
I hope my kids don't GAF, and love what they love, and stay interested in what they are interested in. But it was nice to hear Wheaton's remarks, because he really worked to encourage the young woman. I feel like there's a cultural shift under way, where being nerdy is cool. Knowing stuff is popular, and gaming is just recreation, not a stigma. May this shift grow exponentially.